Two recent papers1,2 report extensive nuclear DNA sequence from a 38,000‐year‐old Neandertal fossil, comparing it to modern humans and estimating when it diverged from, and whether it contributed to, our gene pool. Based on 65,250 and over a million base‐pairs of sequence across the genome, respectively, the groups arrived at slightly different interpretations. The data are an exciting and interesting new contribution, but are not surprising, and a sense of history and question helps put them in perspective. BioEssays 29: 105–110, (...) 2007. © 2007 Wiley Periodicals, Inc. (shrink)

This book provides practical and research-based chapters that offer greater clarity about the particular kinds of teacher reflection that matter and avoids talking about teacher reflection generically, which implies that all kinds of reflection are of equal value.

From the time of Reid through Coleridge to T. H. Green, Hume was interpreted as a sceptic and as a wholly negative philosopher. And from their perspective such an interpretation no doubt makes some sense, given the vested interest in religion and the absolute of the idealists: from that perspective it is an essential part of a positive position that it take one beyond the realm of ordinary objects known by sense experience to a realm of entities that transcend that (...) world of everyday life. That interpretation lingers on, like bad jokes, to retail in Philosophy 100 classes. On the other hand, in an age where the demand that one have access to a transcendent entity is less insistent, it has become possible to challenge the orthodox reading of Hume. The first to do this was Norman Kemp Smith, who argued that, while Hume was a sceptic, he in fact also had a positive view, not to be sure that of Reid & Co., but that of anaturalist, that is, one who holds that our beliefs, and our moral commitments, are none of them rational, none of them products of reason, but rather are products of our instinctive and passionate natures. This interpretation continues to have important defenders such as Popkin and Stroud. More recently, however, some scholars have gone further and argued that there are good senses in which Hume is not a sceptic, and that he constructs a case that our instinctual beliefs are not only natural but also rational. Major works defending this reading of Hume as a naturalized epistemologist are those of Livingston and Jones. The Kemp Smith interpretation has, however, found a major new defender in John Wright'sThe Sceptical Realism of David Hume. (shrink)

ContentsThe Self-Images of a Discipline: A Genealogy of International Relations Theory/Steve SmithThe End of the Cold War and International Relations: Some Analytic and Theoretical Conclusions/Fred HallidayInternational Relations and the Triumph of Capitalism/Richard LittleInternational Political Theory and the Idea of World Community/Chris BrownThe Political Theory of International Society/Robert H. JacksonInternational Political Theory and the Global Environment/Andrew HurrellPolitical Economy and International Relations/Susan StrangeRe-visioning Security/J. Ann TicknerThe Level of the Analysis Problem in International Relations Reconsidered/Barry BuzanThe Post-Positivist Debate: Reconstructing Scientific Enquiry and (...) International Relations Theory After Enlightenment's Fall/John A. VasquezNeo-realism in Theory and Practice/Andrew LinklaterInternational Politics and Political Theory/Jean Bethke ElshtainQuestions About Identity in International Relations/Marysia Zalewski and Cynthia EnloeInternational Relations and the Concept of the Political/R. B. J. WalkerDare Not to Know: International Relations Theory Versus the Future/Ken Booth. (shrink)

The neuropsychology of religious activity in normal and selected clinical populations is reviewed. Religious activity includes beliefs, experiences, and practice. Neuropsychological and functional imaging findings, many of which have derived from studies of experienced meditators, point to a ventral cortical axis for religious behavior, involving primarily the ventromedial temporal and frontal regions. Neuropharmacological studies generally point to dopaminergic activation as the leading neurochemical feature associated with religious activity. The ventral dopaminergic pathways involved in religious behavior most closely align with the (...) action-extrapersonal system in the model of 3-D perceptual–motor interactions proposed by Previc . These pathways are biased toward distant space and also mediate related extrapersonally dominated brain functions such as dreaming and hallucinations. Hyperreligiosity is a major feature of mania, obsessive-compulsive disorder, schizophrenia, temporal-lobe epilepsy and related disorders, in which the ventromedial dopaminergic systems are highly activated and exaggerated attentional or goal-directed behavior toward extrapersonal space occurs. The evolution of religion is linked to an expansion of dopaminergic systems in humans, brought about by changes in diet and other physiological influences. (shrink)

One Religious consciousness and ultimate reality i Like everything that enters human experience, religion has a universal meaning which remains essentially ...

This commentary focuses on the larger implications of Grodzinsky's hypothesis. Although Grodzinsky argues persuasively that the syntactic comprehension deficits in Broca's aphasia involve mainly an inability to comprehend sentences requiring a transformational movement of phrasal constituents, his larger claim for a distinct and dedicated “language organ” in the left hemisphere is much less tenable.

The transparent sea urchin embryo provides a laboratory for study of morphogenesis. The calcareous endoskeleton is formed by a syncytium of mesenchyme cells in the blastocoel. The locations of mesenchyme in the blastocoel, the size of the skeleton, and even the branching pattern of the skeletal rods, are governed by interactions with the blastula wall. Now Guss and Ettensohn(1) show that the rate of deposition of CaCO3 in the skeleton is locally controlled in the mesenchymal syncytium, as is the pattern (...) of expression of three genes involved in skeleton formation. They propose that short range signals emanating from the blastula wall regulate many aspects of the biomineralization process. (shrink)

The COVID-19 pandemic prompted immense work on the investigation of the SARS-CoV-2 virus. Rapid, accurate, and consistent interpretation of generated data is thereby of fundamental concern. Ontologies––structured, controlled, vocabularies––are designed to support consistency of interpretation, and thereby to prevent the development of data silos. This paper describes how ontologies are serving this purpose in the COVID-19 research domain, by following principles of the Open Biological and Biomedical Ontology (OBO) Foundry and by reusing existing ontologies such as the Infectious Disease Ontology (...) (IDO) Core, which provides terminological content common to investigations of all infectious diseases. We report here on the development of an IDO extension, the Virus Infectious Disease Ontology (VIDO), a reference ontology covering viral infectious diseases. We motivate term and definition choices, showcase reuse of terms from existing OBO ontologies, illustrate how ontological decisions were motivated by relevant life science research, and connect VIDO to the Coronavirus Infectious Disease Ontology (CIDO). We next use terms from these ontologies to annotate selections from life science research on SARS-CoV-2, highlighting how ontologies employing a common upper-level vocabulary may be seamlessly interwoven. Finally, we outline future work, including bacteria and fungus infectious disease reference ontologies currently under development, then cite uses of VIDO and CIDO in host-pathogen data analytics, electronic health record annotation, and ontology conflict-resolution projects. (shrink)

The concept of action-research has been developed during the last decade, mainly at the Research Center for Group Dynamics, University of Michigan, Ann Arbor and at the Commission for Community Interrelations of the American Jewish Congress—centers founded by the late Kurt Lewin whose original and creative mind has made many contributions to social-psychological and sociological research. I owe my acquaintance with this new approach to the Research Center, particularly to Ronald Lippitt and Alvin Zander. Yet most of the following observations (...) are based on my research experience during the last four years. The responsibility for what I am saying is, therefore, completely my own. (shrink)

Classical embryological studies have provided a great deal of information on the autonomy and stability of cell fate determination in early sea urchin embryos. However, these studies were limited by the tools available at the time, and the interpretation of the results of these experiments was limited by the lack of information available at the molecular level. Recent studies which have re‐examined classical experiments at the molecular level have provided important new insights into the mechanism of determination in sea urchins, (...) and require us to re‐evaluate some long standing theories on the process of differentiation. (shrink)

This volume collects contributions from leading scholars of early modern philosophy from a wide variety of philosophical and geographic backgrounds. The distinguished contributors offer very different, competing approaches to the history of philosophy.Many chapters articulate new, detailed methods of doing history of philosophy. These present conflicting visions of the history of philosophy as an autonomous sub-discipline of professional philosophy. Several other chapters offer new approaches to integrating history into one's philosophy by re-telling the history of recent philosophy. A number of (...) chapters explore the relationship between history of philosophy and history of science.Among the topics discussed and debated in the volume are: the status of the principle of charity; the nature of reading texts; the role of historiography within the history of philosophy; the nature of establishing proper context. (shrink)

The rationale for pesticide use in agriculture is that costs associated with pesticide pollution are to be justified by its benefits, but this is not so obvious. Valuing the benefits by simple economic analysis has increased pesticide use in agriculture and consequently produced pesticide-induced “public ills.” This paper attempts to explore the research gaps of the economic and social consequences of pesticide use in developing countries, particularly with an example of Nepal. We argue that although the negative sides of agricultural (...) development, for example- soil, water, and air pollution; pest resistance and resurgence; bioaccumulation, bio-magnification; and loss of biodiversity and ecosystem resilience caused by the use of pesticides in agriculture, are “developmental problems” and are “unintentional,” the magnitude may be increased by undervaluing the problems in the analysis of its economic returns. Despite continuous effort for holistic system analyses for studying complex phenomena like pesticides impacts, the development within the academic science has proceeded in the opposite direction that might have accelerated marginalization of the third world subsistence agricultural communities. We hypothesize that, if these adversities are realized and accounted for, the benefits from the current use of pesticides could be outweighed by the costs of pollution and ill human health. This paper also illustrates different pathways and mechanisms for marginalization. In view of potential and overall negative impacts of pesticide use, we recommend alternative ways of controlling pests such as community integrated pest management (IPM) along with education and training activities. Such measures are likely to reduce the health and environmental costs of pesticide pollution, and also enhance the capabilities of third world agricultural communities in terms of knowledge, decision making, innovation, and policy change. (shrink)

Rereads classical figures in continental thought, takes up current topics in the legacy of political theory, and analyzes and evaluates Foucault's work as a prime manifestation of the complicated modern interface between truth and power, institution and liberation.